I think Mosrites sound awesome through the old tuck and roll Kustoms. They are one of the best clean sounds out there if you ask me. (I know, I know, nobody did...

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I normally use a tweed Peavey Classic 50 tube amp, 2X12 combo with an old Peavey 2X12 cabinet with Jensens in it, that sounds pretty good. I just got a deal on a Fender Frontman 2X12 100 watt (solid state) thats not bad, but the reverb is crappy I think. That thing is LOUD! I have a '66 Fender brown tolex 2X12 cabinet with EV's in it that I'd like to run the Fender through, but I need to install an external speaker jack in the amp, it has none. I also have a '56 Fender Tremolux (no reverb) that I haven't gotten around to plugging the Mosrite into yet.
Speaking of the modeling amps, I have one of those Vox Valvetronix 100 watters, all I use on it is the AC30 setting with a Digitech Brian May pedal when I play, or ATTEMPT to play Queen songs. I get a good Brian May sound using a Strat, now, if I could only play like him......

I don't like to deal with all of those programs and stuff on it, I tend to be pretty basic and don't like to deal with much when I'm playing out.